Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)
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چکیده
منابع مشابه
Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)
In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. We studied pain mechanisms in the African naked mole-rat, an unusual rodent species that lacks pain-related neuropeptides (e.g., substance P) in cutaneous sensory fibers. Naked mole-rats show a unique and remarkable lack of pain-related behaviors to two potent al...
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Telomere length, an important feature of life span control, is dependent on the activity of telomerase (a key enzyme of the telomere-length-maintaining system). Telomerase RNA is a component of telomerase and, thus, is crucial for its activity. The structures of telomerase RNA genes and their promoter regions were compared for the long-living naked mole rat and different organisms. Two rare pol...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2008
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0060013